Ischemia
Chemokines are differentially regulated in mouse cardiac fibroblasts
Published in Gene Therapy Weekly, August 17th, 2006
"Ischemia-reperfusion injury in the heart is characterized by marked infiltration of neutrophils in the myocardial interstitial space. Studies in human, canine, and murine models have revealed OSM expression in infiltrating leukocytes.
"In an effort to assess possible roles of OSM in the myocardium, we used cardiac fibroblasts (mCFs) isolated from adult mouse heart to determine whether recombinant murine OSM regulates the synthesis and release of MIP2/CXCL2, KC/CXCL1, and LIX/CXCL5, which are three...
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Source: Gene Therapy Weekly (2006-08-17)
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