Adenovirus Pathogenesis
Adenovirus type 2 and type 5 E1A genes are expressed at different levels
Published in Gene Therapy Weekly, August 17th, 2006
According to a study from Germany, "Adenoviruses are an extensively studied system for modeling oncogenesis and for experimental cancer therapy.
"The most commonly analyzed virus types are 2 and 5, and little distinction has been made between them in past studies. Adenoviruses used for therapeutic purposes are frequently hybrids between these types, including the prototype dl1520/Onyx015."
"We tested the replication of the wild-type viruses WtD (a hybrid of the type 2 E1 region and type 5) and dl309 (type 5) in comparison with the mutants dl1520 (hybrid) and...
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Source: Gene Therapy Weekly (2006-08-17)
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