Reconstructive Surgery
Skin flap viability rallies with proangiogenic gene therapy treatment
Published in Gene Therapy Weekly, August 17th, 2006
According to recent research published in the American Journal of Physiology - Heart and Circulatory Physiology, "Skin ischemic necrosis due to vasospasm and/or insufficient vascularity is the most common complication in the distal portion of the skin flap in reconstructive surgery."
N. Huang and colleagues, Hospital for Sick Children, said, "This project was designed to test our hypothesis that preoperative subdermal injection of adenoviral vectors encoding genes for vascular endothelial growth factor-165 (Ad.VEGF165 ) or endothelial nitric oxide (NO) synthase...
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Source: Gene Therapy Weekly (2006-08-17)
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