Cancer Therapy
Ganglioside modulates tumor suppressor-mediated transcriptional induction
Published in Gene Therapy Weekly, August 24th, 2006
"The simple ganglioside GM3 has been shown to have anti-proliferative effects in several in vitro and in vivo cancer models. Although the exogenous ganglioside GM3 has an inhibitory effect on cancer cell proliferation, the exact mechanism by which it prevents cell proliferation remains unclear," wrote H.J. Choi and colleagues, Sungkyunkwan University.
"Previous studies showed that MDM2 is an oncoprotein that controls...
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Source: Gene Therapy Weekly (2006-08-24)
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