Cardiology
Cardiovascular expression during development and adulthood clarified
Published in Gene Therapy Weekly, August 24th, 2006
"Large deletions in WNK1 are associated with inherited arterial hypertension. WNK1 encodes two types of protein: a kidney-specific isoform (KS-WNK1) lacking kinase activity and a ubiquitously expressed full-length isoform (L-WNK1) with serine threonine kinase activity.
"Disease is thought to result from hypermorphic mutations increasing the production of one or both isoforms. However, the pattern of L-WNK1 expression remains poorly characterized," wrote C. Delaloy and colleagues, INSERM...
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Source: Gene Therapy Weekly (2006-08-24)
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