Glioblastoma
Telomerase inhibition impairs tumor growth in glioblastoma xenografts
Published in Gene Therapy Weekly, August 24th, 2006
"Telomerase is a specialized DNA polymerase that is required to replicate the ends of linear chromosomes, the telomeres. The majority of human cancers express high levels of telomerase activity that is permissive for tumor growth because it provides cells with an extended proliferative potential," wrote M.L. Falchetti and colleagues, CNR.
"Additionally, telomerase exerts cell growth promoting functions and favors cell survival. Human glioblastoma multiforme (GBM) cells express high level of telomerase activity owing to the...
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Source: Gene Therapy Weekly (2006-08-24)
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