Drug Delivery

Lung delivery of superoxide dismutase is enhanced by perfluorochemical liquids

Published in Gene Therapy Weekly, August 24th, 2006

A study from the United States has documented that the lung delivery of superoxide dismutase (SOD) is enhanced by perfluorochemical (PFC) liquids.

"Previous studies suggest acute lung injury (ALI) in premature newborns is associated with relative deficiency of antioxidant enzymes that may be ameliorated by recombinant human SOD (rhSOD).

"PFCs are distributed homogeneously and support gas exchange in diseased lungs. We investigated whether PFCs could provide an effective delivery system for rhSOD," wrote L. Brunelli and colleagues, Alfred I. DuPont Hospital for Children.

They explained, "Juvenile rabbits were lung-lavaged, treated...

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Source: Gene Therapy Weekly (2006-08-24)

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