Published in Gene Therapy Weekly, August 24th, 2006
"HBV, as a major cause of acute and chronic hepatitis in humans, contains a partial double-stranded circular DNA genome of 3.2 kb that is transcribed into the 3.5-, 2.4-, 2.1-, and 0.7-kb viral transcripts by the host RNA polymerase II. The HBV X (HBx) gene is consistently expressed in all four HBV viral mRNAs and is thus an ideal target for developing viral inhibitors via a gene therapeutic approach.
"In this study, we show that two HBx-specific small interfering RNAs (siRNA),...
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