Ischemia

Hypoxia-mediated gene induction in cardiomyocytes promotes cell death

Published in Gene Therapy Weekly, August 24th, 2006

According to recent research from the United States, Gene 33/RALT is induced by hypoxia in cardiomyocytes, where it promotes cell death by suppressing phosphatidylinositol 3-kinase and extracellular signal-regulated kinase survival signaling.

"Ischemia in the heart deprives cardiomyocytes of oxygen, triggering cell death (myocardial infarction). Ischemia and its cell culture model, hypoxia, elicit a stress response program that contributes to cardiomyocyte death; however, the molecular components required to promote this process remain nebulous," wrote D.Z. Xu and colleagues, Tufts New England Medical Center.

"Gene 33 is a 50-kDa cytosolic adapter...

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Source: Gene Therapy Weekly (2006-08-24)

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