Published in Gene Therapy Weekly, August 24th, 2006
"The survival and growth of tumor cells in a foreign environment is considered a rate-limiting step during metastasis. To identify genes that may be essential for this process, we isolated highly metastatic variants from a poorly metastatic human melanoma cell line and performed expression analyses of metastases and primary tumors from these cells," scientists in the United States reported.
"GPR56 is among the genes markedly down-regulated in the metastatic variants. We show that overexpression of GPR56...
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