Published in Gene Therapy Weekly, August 24th, 2006
Study 1: According to recent research published in the Journal of Cellular Physiology, T-lymphoblastoid CEM cell apoptosis involves caspase-dependent cleavage of 170-kDa P-glycoprotein (P-gp).
"Multi drug resistance (MDR) mediated by the drug efflux protein, 170-kDa P-glycoprotein (P-gp), is one mechanism that tumor cells use to escape cell death induced by chemotherapeutic drugs. Moreover, evidence suggests that cell lines expressing high levels of 170-kDa P-gp are less sensitive to caspase-mediated apoptosis induced by a wide range of death stimuli,...
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