Cancer Gene Therapy
Antiapoptosis function of papillomavirus oncoprotein requires inhibited Bax
Published in Gene Therapy Weekly, September 7th, 2006
"Oncogenic types of HPVs cause cervical cancer in humans. The antiapoptotic viral E6 gene has been identified as a key factor for maintaining the viability of HPV-positive cancer cells.
"Although E6 has the potential to modulate many apoptosis regulators, the crucial apoptotic pathway blocked by endogenous E6 in cervical cancer cells remained unknown," wrote M. Vogt and colleagues, Deutsche Krebsforschungszentrum.
"Using RNA interference (RNAi), here, we show that...
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Source: Gene Therapy Weekly (2006-09-07)
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