Cell Biology
Protein-mediated post-docking is required for pancreatic beta-cell exocytosis
Published in Gene Therapy Weekly, September 7th, 2006
"Although the assembly of a ternary complex between the SNARE proteins syntaxin-1, SNAP25 and VAMP2 is known to be crucial for insulin exocytosis, the mechanisms controlling this key event are poorly understood. We found that pancreatic beta-cells express different isoforms of tomosyn-1, a syntaxin-1-binding protein possessing a SNARE-like motif," wrote S. Cheviet and colleagues, University of Lausanne.
"Using atomic force microscopy we show that the SNARE-like domain of tomosyn-1 can form a complex with...
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Source: Gene Therapy Weekly (2006-09-07)
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