DNA Research
Prostate cancer cells receive targeted therapy from monoclonal antibodies
Published in Gene Therapy Weekly, September 7th, 2006
"J591 (mAb) has high affinity for prostate specific membrane antigen (PSMA) on prostate cancer (PCA) cells. We coupled polyethylene glycol-J591 (PEGylated J591) to a salicyl hydroxamic acid (SHA)-derivatized polyethylenimine (PEI)/DNA-beta gal vector to investigate the specificity and efficiency of targeting PSMA in PCA cells through encapsulation," wrote S. Moffatt and colleagues, University of Texas.
"Coupling was facilitated via the high affinity interaction between phenyl(di)boronic...
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Source: Gene Therapy Weekly (2006-09-07)
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