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Sindbis viral vector enables gene-directed enzyme-prodrug therapy

Published in Gene Therapy Weekly, September 7th, 2006

Scientists from the United States reported on tumor-specific in vivo transfection with hepatitis specific virus-1 (HSV-1) thymidine kinase gene using a Sindbis viral vector as a basis for prodrug ganciclovir activation and positron emission tomography (PET).

"One type of gene therapy of tumors, gene-directed enzyme-prodrug therapy (GDEPT), holds considerable promise, although practical considerations limit its clinical applicability. These include the lack of acceptable noninvasive methods that are adaptable to humans for selective tumor targeting of the therapeutic genetic material," wrote J.C. Tseng and colleagues, New York University.

They...

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