Immunotherapy
IgG1 effector functions modulated through engineering of its hinge region
Published in Gene Therapy Weekly, September 7th, 2006
"We report here the engineering of a humanized anti-human EphA2 mAb (mAb 12G3H11) in an effort to explore the relationship between the hinge of a human IgG1 and its effector functions," wrote W.F. Dallacqua and colleagues, MedImmune.
"mAb 12G3H11, used here as a model, is directed against the human receptor tyrosine kinase EphA2, which is an actively investigated target for cancer therapy due to its up-regulation in many cancer cells. Various rational modifications were introduced into the hinge region of mAb...
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Source: Gene Therapy Weekly (2006-09-07)
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