Published in Gene Therapy Weekly, September 7th, 2006
"The influences of targeted heterozygous inactivation of type II (pro)collagen gene (Col2al) on eye structures in the 15-month-old C57BL/6JO-laHsd mouse was studied," wrote K. Kaarniranta and colleagues, Kuopio University.
"The eyes were collected from C57BL mice heterozygous for a targeted inactivation of one allele of the Col2al gene (Col2al(±) mice). The eyes of C57BL mice with normal gene alleles were used as controls (Col2al(+/+) mice). Ocular histology was analyzed from tissue sections, stained with hematoxylin and eosin, toluidine blue and...
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