Ophthalmology
Stickler syndrome mouse model developed
Published in Gene Therapy Weekly, September 7th, 2006
"The influences of targeted heterozygous inactivation of type II (pro)collagen gene (Col2al) on eye structures in the 15-month-old C57BL/6JO-laHsd mouse was studied," wrote K. Kaarniranta and colleagues, Kuopio University.
"The eyes were collected from C57BL mice heterozygous for a targeted inactivation of one allele of the Col2al gene (Col2al(±) mice). The eyes of C57BL mice with normal gene alleles were used as controls (Col2al(+/+) mice). Ocular histology was analyzed from tissue sections, stained with hematoxylin and eosin, toluidine blue and...
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Source: Gene Therapy Weekly (2006-09-07)
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