Published in Gene Therapy Weekly, September 14th, 2006
Study 1: A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells was revealed by scientists in the United States.
"Nonspecific effects triggered by small interfering RNAs (siRNAs) complicate the use of RNA interference (RNAi) to specifically downregulate gene expression. To uncover the basis of these nonspecific activities, we analyzed the effect of chemically synthesized siRNAs on mammalian double-stranded RNA (dsRNA)-activated signaling pathways," wrote J.T. Marques and colleagues, Cleveland Clinic Foundation.
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