Apoptosis

Breast cancer cell apoptosis and growth inhibition induced by truncated cadherin

Published in Gene Therapy Weekly, September 14th, 2006

In a recent study, researchers in France reported that a soluble truncated cadherin induces breast cancer cell apoptosis and growth inhibition.

"To identify the characteristics and function of the truncated cadherin cDNA which encodes a soluble molecule containing the sequence of VE-cadherin extracellular domain repeats from repeat 1 to 4 (designated as CED1-4) and a secreting signal peptide at N terminal, a pMSCV/CED1-4 vector was constructed," wrote X.Y. Shi and colleagues, Pharmacie de Rouen.

"Recombinant retrovirus ReCED1-4 and ReEmpty were produced by 293 package cells and transfected into MDA-MB435 human breast cancer cells. The expression of...

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Source: Gene Therapy Weekly (2006-09-14)

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