Adverse Drug Reaction
Acetaminophen hepatotoxicity is influenced by c-jun N-terminal kinase
Published in Gene Therapy Weekly, September 14th, 2006
"In searching for effects of APAP on hepatocytes downstream of its metabolism that may participate in hepatotoxicity, we examined the role of stress kinases," wrote B.K. Gunawan and colleagues, University of California.
"Mouse hepatocytes and C57BL/6 mice were administered a toxic dose of APAP with or without SP600125, a chemical JNK inhibitor. JNK activity as reflected in phospho-c-jun levels, serum Ala transaminase (ALT), and liver histology were assessed. Similar experiments were repeated in JNK1 and JNK2...
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Source: Gene Therapy Weekly (2006-09-14)
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