Neuroscience
Mediation of anticonvulsant and sedative effects of loreclezole clarified
Published in Gene Therapy Weekly, September 14th, 2006
"The majority of inhibitory neurotransmission in the brain is mediated by the GABA(A) receptor. The anticonvulsant loreclezole largely acts by potentiating GABA(A) receptors containing beta 2 and beta 3 subunits.
"We used a genetically modified mouse containing a loreclezole-insensitive beta 2 subunit (beta 2N265S) to determine the role of this subunit in mediating the sedative and anticonvulsive effects of loreclezole," wrote J.O. Groves and...
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Source: Gene Therapy Weekly (2006-09-14)
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