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Genetics

Findings from the United States and Portugal advance knowledge in genetics research

Published in Gene Therapy Weekly, September 21st, 2006

Reports from the United States and Portugal highlight recent research in genetics.

Study 1: A study from the United States has documented a novel anti-inflammatory role for glycogen synthase kinase-3 beta (GSK-3 beta) in the inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta)-induced inflammatory gene expression.

"GSK-3 beta is a Ser/Thr kinase with a broad array of cellular targets, such as cytoskeletal proteins and transcription factors. Recent studies with GSK-3 beta-null mice showed impaired NF kappa B-mediated survival responses.

"Because NF kappa B serves a dual role as a key regulator of...

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