Published in Gene Therapy Weekly, September 21st, 2006
"The antiandrogen FLU is used primarily for prostate cancer and is an idiosyncratic hepatotoxicant that sometimes causes severe liver problems. To investigate FLU's overt hepatic effects, especially on inducible drug clearance-related gene networks, FLU's hepatic gene expression profile was examined in female Sprague-Dawley rats using approximately 22,500 oligonucleotide microarrays," wrote K.J. Coe and colleagues, Amgen.
"Rats were dosed...
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