Published in Gene Therapy Weekly, September 21st, 2006
Study 1: Recent research published in the journal Nature Cell Biology has reported on the regulation of mitotic entry by microcephalin and its overlap with ataxia-telangiectasia mutated and Rad3 related (ATR) signalling.
"ATR-Seckel syndrome and autosomal recessive primary microcephaly (MCPH) syndrome share clinical features. RNA interference (RNAi) of MCPH1 have implicated the protein it encodes as a DNA-damage response protein that regulates the transcription of Chk1 and BRCA1, two genes involved in the response to DNA damage.
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