Published in Gene Therapy Weekly, September 21st, 2006
"We have previously shown that Tc1 CD8+ T cells have in vitro and in vivo effector activity against PC infection in mice. Because these cells have preferential expression of CXCR3, we investigated whether CXCR3 was required for host defense activity against PC," wrote F. McAllister and colleagues, University of Pittsburgh.
"Mice deficient in CXCR3 but CD4+ T cell intact, showed an initial delay but were able to clear the infectious challenge, indicating that CXCR3 signaling is not essential for clearance of PC. CD4-depleted mice had lower levels...
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