Published in Gene Therapy Weekly, September 21st, 2006
"Native lung SP-C is a 4.2-kDa acylpeptide that associates with alveolar surfactant phospholipids via a transmembrane alpha-helix. This helix contains mainly Val, although poly-Val is inefficient in helix formation, and helical SP-C can spontaneously convert to beta-sheet aggregates and amyloid-like fibrils," wrote H. Johansson and colleagues, Swedish University of Agricultural Science.
"SP-C is cleaved out from a 21-kDa integral membrane protein, proSP-C, in the alveolar type...
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