Respiratory Medicine

Pro-surfactant protein domain binds to an unfolded transmembrane segment

Published in Gene Therapy Weekly, September 21st, 2006

According to recent research from Sweden, the Brichos domain-containing C-terminal part of pro-surfactant protein C (SP-C) binds to an unfolded poly-Val transmembrane segment.

"Native lung SP-C is a 4.2-kDa acylpeptide that associates with alveolar surfactant phospholipids via a transmembrane alpha-helix. This helix contains mainly Val, although poly-Val is inefficient in helix formation, and helical SP-C can spontaneously convert to beta-sheet aggregates and amyloid-like fibrils," wrote H. Johansson and colleagues, Swedish University of Agricultural Science.

"SP-C is cleaved out from a 21-kDa integral membrane protein, proSP-C, in the alveolar type...

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Source: Gene Therapy Weekly (2006-09-21)

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