Cancer Gene Therapy

DNA methyltransferase gene transcription induced in malignant T lymphocytes

Published in Gene Therapy Weekly, September 28th, 2006

According to a study from the United States, STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes.

"In this study, we demonstrated that STAT3, a well-characterized transcription factor expressed in continuously activated oncogenic form in the large spectrum of cancer types, induces in malignant T lymphocytes the expression of DNMT1, the key effector of epigenetic gene silencing," wrote Q. Zhang and colleagues, University of Pennsylvania.

"STAT3 binds in vitro to 2 STAT3 SIE/GAS-binding sites identified in promoter 1 and enhancer 1 of the DNMT1 gene. STAT3 also binds to the promoter 1 region and induces...

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Source: Gene Therapy Weekly (2006-09-28)

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