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Atherosclerosis

Atherosclerotic plaque stability is affected by novel candidate genes

Published in Gene Therapy Weekly, October 5th, 2006

A study from England has reported on novel candidate genes in unstable areas of human atherosclerotic plaques.

"Comparison of gene expression in stable versus unstable atherosclerotic plaque may be confounded by interpatient variability. The aim of this study was to identify differences in gene expression between stable and unstable segments of plaque obtained from the same patient," wrote M. Papaspyridonos and colleagues, King's College London.

"Human carotid endarterectomy specimens were segmented and macroscopically classified using a morphological classification system. Two analytical methods, an intraplaque and an interplaque analysis, revealed...

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