Breast Cancer

Breast cancer diminished survival correlates with topoisomerase expression

Published in Gene Therapy Weekly, October 5th, 2006

In a recently published article, scientists in the United States reported that topoisomerase II alpha (topo II alpha) expression correlates with diminished disease-free survival in invasive breast cancer.

"Topo II alpha plays a role in DNA replication and is the molecular target for anthracycline-based chemotherapy. The purpose of this study was to evaluate the relationship between Topo II alpha expression and survival in patients with invasive breast cancer," wrote J.K. O'Connor and colleagues, Tulane University.

"Formalin-fixed, paraffin-embedded tumor specimens from 24 women with invasive breast cancer were stained for Topo II alpha expression....

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Source: Gene Therapy Weekly (2006-10-05)

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