Published in Gene Therapy Weekly, October 5th, 2006
"Eukaryotic DNA replication begins with the binding of a six subunit ORC to DNA. To study the assembly and function of mammalian ORC proteins in their native environment, HeLa cells were constructed that constitutively expressed an epitope-tagged, recombinant human Orc2 subunit that had been genetically altered," wrote I. Radichev and colleagues, National Institute of Child Health & Human Development.
"Analysis of these cell lines...
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