Genetics & Genomics

Specific domains required for origin recognition complex nuclear localization

Published in Gene Therapy Weekly, October 5th, 2006

According to recently published from the United States, genetic analysis of human ORC2 reveals specific domains that are required in vivo for assembly and nuclear localization of the origin recognition complex (ORC).

"Eukaryotic DNA replication begins with the binding of a six subunit ORC to DNA. To study the assembly and function of mammalian ORC proteins in their native environment, HeLa cells were constructed that constitutively expressed an epitope-tagged, recombinant human Orc2 subunit that had been genetically altered," wrote I. Radichev and colleagues, National Institute of Child Health & Human Development.

"Analysis of these cell lines...

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Source: Gene Therapy Weekly (2006-10-05)

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