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Helicobacter Pylori

 Helicobacter pylori induces heparin-binding epidermal growth factor expression

Published in Gene Therapy Weekly, October 5th, 2006

According to a study from England, Helicobacter pylori can induce heparin-binding epidermal growth factor (HB-EGF) expression via gastrin and its receptor.

"Both gastrin and H. pylori have been shown capable of up-regulating gene expression and protein shedding of HB-EGF. Furthermore, the bacteria have previously been shown to induce serum hypergastrinemia in infected individuals. The aim of this work was to assess the extent to which the ability of H. pylori to up-regulate expression of HB-EGF can be attributed to its effect on gastrin," wrote J.H. Dickson and colleagues, University of Nottingham.

"Gastric cells, transfected...

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