Herpes Simplex Virus
Herpes simplex virus hydrophobic helices enhance virus infection and fusion
Published in Gene Therapy Weekly, October 5th, 2006
"Entry of herpes simplex virus into cells occurs by fusion and requires four glycoproteins. gD serves as the receptor binding glycoprotein. Of the remaining glycoproteins, gH carries structural and functional elements typical of class 1 fusion glycoproteins, in particular alpha-helix 1 (alpha-H1), with properties of a candidate fusion peptide, and two heptad repeats," wrote T. Gianni and colleagues, University of Bologna.
"Here, we characterized alpha-H2 and compared it to...
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Source: Gene Therapy Weekly (2006-10-05)
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