Gene Therapy Weekly

Antisense Technology - Neurodegenerative disease therapy can utilize antisense oligonucleotides

Colitis - Colitis therapeutic target identified

Gene Silencing - Myostatin silenced in embryonic myoblast differentiation

Neuroscience - Heterotopia formation occurs in rat neocortex after RNA interference knockdown

Stem Cell Research - Embryonic stem cell reversible gene expression induced by a RNA vector

Adverse Drug Reaction - Cardiotoxicity of the cancer therapeutic agent imatinib mesylate documented

Allergy & Immunology - Lymphoblast and T helper cell proliferation affected by interleukin

Alzheimer Disease - Prion protein peptide toxicity studied in neuronal and non-neuronal cells

Apoptosis - Pro-apoptotic effects in HeLa cells require retinoic acid responsive gene

Apoptosis - Tumor cell induced apoptosis can be inhibited by survivin

Arthritis - E2F decoy ODN may provide useful approach for treatment of joint destruction in arthritis

Arthritis - Increased arthritis susceptibility reported in transgenic mice

Awards - Eurand announces winners of 2006 Eurand Award Program

Bladder Inflammation - LPS-induced urinary bladder inflammation is attenuated by prostasin

Business Update - Clinical Data, others publish results of U.S. FDA-led assessment of microarray gene expression data

Business Update - Cobra to support novel gene therapy trials

Business Update - Crucell and UCB sign STAR license agreement for production of monoclonal antibodies

Business Update - CyGene announces Spanish-language website to promote genetic testing products to Hispanic market

Business Update - CytoDyn forming product development team for rapid development of DNA-based influenza pre-vaccines

Business Update - ExonHit's SpliceArray Portal gives interactive access to new resolution of genome expression

Business Update - Exposure trial by leading allergist shows Allerca cat is hypoallergenic

Cancer Gene Therapy - Anti-tumor immune response induced by transfected dendritic cells

Cancer Gene Therapy - Cell cycle-specific promoter activity changes detected in adenoviral gene therapy

Cancer Gene Therapy - Colorectal carcinoma increased growth factor is independent of tumor burden

Cancer Gene Therapy - Gene therapy model reveals unique risk factors for insertional mutagenesis

Cancer Gene Therapy - Glioblastoma growth suppressed by inhibition of Tyr phosphatase

Cancer Gene Therapy - Immunotherapy achieved using leukemic antigen containing dendritic cells

Cancer Gene Therapy - Nasopharyngeal cancer cell metastasis inhibited by RNA interference

Cancer Gene Therapy - Nasopharyngeal carcinoma antitumor effect induced by interferon gene transfer

Cancer Therapy - Anti-cancer agent and hypoxia-inducible factor-1 blocker join to staunch tumor growth

Cancer Therapy - Neuroblastoma treated by surgical excision and whole tumor cell vaccination

Cardiology - Aortic smooth muscle cell chemokine expression mediated by signaling pathway

Cardiology - Myocardial function improves in ischemic hearts of porcine models given proangiogenic gene therapy

Cell Biology - Thrombin activates AMP-activated protein kinase in endothelial cells

Collaborations - Signature Diagnostics announces clinical research collaboration with OncoMethylome Sciences

Critical Care Medicine - Major bleeding is reversed by recombinant activated factor VII

DNA Research - Claspin operates downstream to direct activation-related signaling

DNA Research - DNA-binding sequence reveals unique requirements for developmental proteins

Dermatology - Chronic psoriasiform skin inflammation requires activated macrophages

Dermatology - Fraser syndrome-like defects provoked by basement membrane destabilization

Developmental Biology - Cell cytoplasmic redistribution abolished by phosphorylation site mutations

Developmental Biology - Differentiated oligodendrocytes stabilized by myelin basic protein microtubules

Developmental Biology - Three-dimensional fetal myocardial tissue formed for long-term cultivation

Developmental Biology - Zebrafish striated myofibril alignment requires obscurin

Diabetes Research - Insulin-receptor activation assay miniaturized

Diabetes Research - Study shows leptin could combat type 2 diabetes

Drug Delivery - Liposomal complex prompts RNA interference in murine vessels

Finance - U.S. NIH awards 5-year grant to Regeneron Pharmaceuticals for Knockout Mouse Project

Gene Delivery - Gene modification was achieved in liver using plasmid DNA encoding Cre recombinase

Gene Delivery - Lipid-based gene delivery reagents have been optimized for use in vertebrate embryos

Gene Research - Leukemic oncogenes identified by phosphoproteomic analysis

Genetics & Genomics - Aberrant gene expression profile is observed in cloned mouse embryos

Heart Failure - Gene therapy inhibition of protein kinase C alpha/beta attenuates heart failure

Hyperoxia - Hyperoxia protection conferred by maintained protein expression

Immunotherapy - Autoantibodies to a specific protein detected in cancer sera

Immunotherapy - Cell survival genes in regulatory T cells are mutationally up-regulated

Ischemia - Direct lung ischemia reperfusion injury is regulated by interleukin

Kaposi Sarcoma - Hypoxia-induced KSHV lytic replication mediated in part through cooperation of HIF-1 alpha

Lung Cancer - Lung carcinoma cell transduction enhanced by baculovirus surface motifs

Medical Devices - Bone apposition occurs to biocoated titanium implants

Medical Devices - Rib defects repaired using recombinant human bone morphogenetic protein

Nephrology - Induced acute liver injury prevented by a receptor agonist

Nephrology - Upregulation induces reactive oxygen species in podocytes

Neuroscience - Hippocampal region is required for long-term memory formation

Neuroscience - Memory deficits are linked to the expression of mutant amyloid precursor protein