Published in Gene Therapy Weekly, October 12th, 2006
Study 1: Hepatocellular carcinoma (HCC) could be linked to the epigenetic silencing of NORE1B, a candidate tumor suppressor.
"In HCC the ras-proto-oncogene is rarely mutated. We therefore studied the possible inactivation of the putative tumor-suppressors and ras-associating proteins, NORE1A, NORE1B, and RASSF1A in HCCs by mutation or epigenetic gene silencing through promoter-CpG hypermethylation. SSCP-analyses, sequencing, and methylation-specific PCR were performed in 28 fibrotic/cirrhotic livers and 40 HCCs," investigators in...
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