Nephrology

Upregulation induces reactive oxygen species in podocytes

Published in Gene Therapy Weekly, October 12th, 2006

According to recently published research from Germany, upregulation of Id-1 via bone morphogenetic protein (BMP)-2 receptors induces reactive oxygen species (ROS) in podocytes.

"BMPs are secreted signaling molecules, which play a major role in kidney development and disease. Here, we show the existence of mRNA for BMP-2 and for the BMP receptors BMPR1A, BMPR1B, BMPRII, ACVR1A, ACVR2, and ACVR2B in differentiated mouse podocytes and the protein expression of BMPR1A in human glomerular podocytes," wrote G. Pache and colleagues, Clinical University of Munster.

"BMP-2 dose dependently increases the free cytosolic Ca²⁺ concentration in...

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Source: Gene Therapy Weekly (2006-10-12)

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