Neuroscience

Nucleus accumbens repressor expression increases behavioral stress responses

Published in Gene Therapy Weekly, October 12th, 2006

According to a study from the United States, induction of inducible cAMP early repressor expression in nucleus accumbens by stress or amphetamine increases behavioral responses to emotional stimuli.

"Previous research has shown that cAMP response element (CRE)-mediated transcription is activated in the nucleus accumbens, a major brain reward region, by a variety of environmental stimuli and contributes to neuroadaptations to these stimuli. CRE-binding protein (CREB) is the most studied activator of CRE transcription and has been implicated in this brain region as a gating mechanism for behavioral responses to emotional stimuli.

"Little attention,...

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Source: Gene Therapy Weekly (2006-10-12)

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