Adverse Drug Reaction

Cardiotoxicity of the cancer therapeutic agent imatinib mesylate documented

Published in Gene Therapy Weekly, October 12th, 2006

According to a study from the United States, the cancer therapeutic agent imatinib mesylate (Gleevac) is cardiotoxic.

"Gleevec is a small-molecule inhibitor of the fusion protein Bcr-Abl, the causal agent in chronic myelogenous leukemia. Here we report ten individuals who developed severe congestive heart failure while on imatinib and we show that imatinib-treated mice develop left ventricular contractile dysfunction," wrote R. Kerkela and colleagues, Thomas Jefferson University.

"Transmission electron micrographs from humans and mice treated with imatinib show mitochondrial abnormalities and accumulation of membrane whorls in both vacuoles and the...

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Source: Gene Therapy Weekly (2006-10-12)

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