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Respiratory Medicine

Lung gene expression profile reveals effect of bitumen fumes

Published in Gene Therapy Weekly, October 12th, 2006

A study from France has chronicled bitumen fume-induced gene expression profile in rat lung.

"Exposure to bitumen fumes during paving and roofing activities may represent an occupational health risk. To date, most of the studies performed on the biological effect of asphalt fumes have been done with regard to their content in carcinogenic polycyclic aromatic hydrocarbons (PAH).

"In order to gain an additional insight into the mechanisms of action of bitumen fumes, we studied their pulmonary effects in rodents following inhalation using the microarray technology," wrote L. Gate and colleagues, Institut National de Recherche et Securite.

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