Published in Gene Therapy Weekly, October 12th, 2006
"HLA-E functions as an inhibitory signaling molecule of natural killer (NK) cell-mediated cytolysis. However, the cell surface expression of HLA-E molecules is quite restricted because of the limited repertoire of binding peptide sequences, such as signal peptides of other HLA molecules, especially on xenogeneic cells," wrote K. Matsunami and colleagues, Osaka University.
"In this study, we successfully determined that position-147 is an important amino acid position for cell surface expression by producing point...
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