Endocrinology
Biological properties of a chimeric gonadotropin clarified
Published in Gene Therapy Weekly, October 19th, 2006
"A chimeric recombinant human gonadotropin, termed C3, demonstrates both follitropic and lutropic bioactivities. The alpha-subunit construct for C3 is comprised of the recombinant wild-type human glycoprotein hormone alpha-subunit," wrote L.M. Garone and colleagues, Serono Research Institute.
"The beta-subunit DNA construct for C3 encodes residues 1-145 from hCG-beta with the exceptions that FSH beta amino acid 88 (D) is substituted for hCG beta amino acid 94 (R) and FSH beta...
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Source: Gene Therapy Weekly (2006-10-19)
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