Enzymology
Human aminopeptidase A enzymatic properties elucidated
Published in Gene Therapy Weekly, October 19th, 2006
"APA is a type II membrane-bound protein implicated in the regulation of blood pressure in the brain renin-angiotensin system. In this study, a recombinant soluble form of APA was expressed in a baculovirus system, purified to homogeneity, and characterized," wrote Y. Goto and colleagues, RIKEN.
"By using synthetic substrates, it was shown that although the enzyme has a rather broad substrate specificity in the absence of Ca2+, the preferential release of acidic amino acid residues was observed in the presence of...
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Source: Gene Therapy Weekly (2006-10-19)
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