Genetics & Genomics

HIV minus strand strong stop DNA transfer stimulated by primer binding site

Published in Gene Therapy Weekly, October 19th, 2006

Recent research from the United States published in the Journal of Biological Chemistry has reported on the stimulation of human immunodeficiency virus 1 (HIV-1) minus strand strong stop DNA transfer by genomic sequences 3' of the primer binding site.

"The mechanism of HIV-1 minus strand transfer was examined using a genomic RNA sequence-based donor-acceptor template system. The donor RNA, D199, was a 199-nucleotide sequence from the 5'-end of the genome to the primer binding site (PBS) and shared 97 nucleotides of homology with the acceptor RNA," wrote M. Song and colleagues, University of Rochester.

"To investigate the influence of RNA...

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Source: Gene Therapy Weekly (2006-10-19)

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