Proteomics

Peptides bind strongly to specific DNA fragments of the Epstein-Barr viral gene

Published in Gene Therapy Weekly, October 19th, 2006

Recent research from Taiwan has reported on unusually strong positive cooperativity in binding of peptides to latent membrane protein-1 (LMP-1) DNA fragments of the Epstein-Barr viral gene.

"The DNA-binding preferences of two oligopeptide amides, (His-Pro-Arg-Lys)(3)NH₂ (HR-12) and (Ser-Pro-Arg-Lys)(3)NH₂ (SP-12), have been examined by quantitative DNase 1 footprinting studies," wrote C.H. Yang and colleagues, Tunghai University.

"Two different DNA fragments were investigated: a pair of 5'-P-32-labeled duplexes from PBR322 with one or other of the complementary strands labeled and a corresponding pair or 5'-P-32-labeled...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of Gene Therapy Weekly

Source: Gene Therapy Weekly (2006-10-19)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry