Diabetes
Data from the United States advance knowledge in diabetes research
Published in Gene Therapy Weekly, October 26th, 2006
Study 1: A study from the United States has reported that targeting Foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action.
"Fasting hyperglycemia, a prominent finding in diabetes, is primarily due to increased gluconeogenesis. The transcription factor Foxol links insulin signaling to decreased transcription of PEPCK and glucose-6-phosphatase (G6Pase) and provides a possible therapeutic target in insulin-resistant states.
"Synthetic, optimized antisense oligonucleotides (ASOs) specifically inhibit Foxol expression. Here we...
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Source: Gene Therapy Weekly (2006-10-26)
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