Published in Gene Therapy Weekly, October 26th, 2006
Study 1: According to recently published research from Japan, accelerated tubular cell senescence occurs in senescence marker protein-30 (SMP30) knockout mice.
"An experimental model with accelerated but not drastic renal senescence seemed useful to recognize the mechanisms of how kidney function deteriorates with age. SMP30, whose expression decreased with age and was sex-independent, is mainly expressed in hepatocytes and proximal tubular cells.
"Therefore, we established a SMP30 deficient strain of mice with a C57BL/6 background by gene...
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