Virology
Studies from the United States and Taiwan describe new findings in virology research
Published in Gene Therapy Weekly, October 26th, 2006
Study 1: According to a study from the United States, vesicular stomatitis virus (VSV) pathogenesis is linked to induction of tumor necrosis factor alpha (TNF-alpha).
"Vesicular stomatitis virus (VSV) matrix (M) protein blocks host mRNA export from the nucleus and thereby inhibits interferon induction in infected cells. M mutants with mutations of methionine 51 (M51) lack this shutoff function.
"We examined pathogenesis of a VSV M mutant with a deletion of M51 (VSV Delta M51) after intranasal infection of BALB/c mice and found an unexpected phenotype,"...
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Source: Gene Therapy Weekly (2006-10-26)
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