Published in Gene Therapy Weekly, October 26th, 2006
"A major issue in the treatment of T-ALL is resistance to chemotherapeutic drugs. Multidrug resistance can be caused by ATP-binding cassette (ABC) transporters. The majority of these proteins have not yet been examined in T-ALL," wrote T. Efferth and colleagues, German Cancer Research Center.
"Using a newly developed microarray for the simultaneous quantification of 38 ABC transporter genes, we observed a consistent overexpression of ABCA2/ABCA3 in clinical samples of ALL. Therefore, we...
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