Endocrinology

Prolactin overexpression in differentiating mammary gland induces benign lesions

Published in Gene Therapy Weekly, October 26th, 2006

According to recently published research from France, local over-expression of prolactin (PRL) in differentiating mouse mammary gland induces functional defects and benign lesions but not carcinoma.

"Experimental, clinical, and epidemiological data support the growth-promoting role of endocrine PRL in mammary tumors. PRL is also produced by the breast, where it is now recognized to act as a growth/survival factor via autocrine/paracrine mechanisms. Recent transgenic (Tg) mouse models have revealed the pro-oncogenic effect of PRL over-expression in virgin mammary glands.

"To address the question whether PRL tumorigenicity was maintained on...

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Source: Gene Therapy Weekly (2006-10-26)

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