Published in Gene Therapy Weekly, October 26th, 2006
"Invasion of brain tumor cells has made primary malignant brain neoplasms among the most recalcitrant to therapeutic strategies. We tested whether the secreted protein Slit2, which guides the projection of axons and developing neurons, could modulate brain tumor cell invasion," wrote T.E. Werbowetski-Ogilvie and colleagues, Montreal Neurology Hospital & Institute.
"Slit2 inhibited the invasion of medulloblastoma cells in a variety of in vitro models. The effect of Slit2 was inhibited by the Robo ectodomain. Time-lapse videomicroscopy indicated...
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