Cancer Therapy

Osteopontin inhibits macrophage nitric oxide synthesis to enhance tumor proliferation

Published in Gene Therapy Weekly, October 26th, 2006

According to recently published research from the United States, osteopontin (OPN) inhibits macrophage nitric oxide synthesis to enhance tumor proliferation.

"Interactions between tumor cells and their host environment can play a major role in regulating survival programs required for tumor progression. OPN is a glycophosphoprotein overexpressed by tumors, and is a key molecule for tumor progression and metastasis. OPN also inhibits expression of autocrine and paracrine inducible nitric oxide synthase (iNOS).

"Given the cytotoxic effects of macrophage NO expression, we hypothesized that tumor-derived OPN inhibits expression of local macrophage iNOS...

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Source: Gene Therapy Weekly (2006-10-26)

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